NABL Accredited TGA at Manesar — USFDA Inspected Thermal Analysis Laboratory

TGA Analysis Laboratory India | Thermogravimetric Analysis Services | NABL

TGA analysis (Thermogravimetric Analysis) services from an NABL-accredited pharmaceutical testing laboratory in India. TGA at our Manesar facility — USFDA Inspected — alongside DSC and XRD for complete solid-state characterisation.

TGA analysis — Thermogravimetric Analysis — is an essential thermal characterisation technique for pharmaceutical development and quality control, measuring the precise mass changes that occur in a substance as temperature increases under controlled atmospheric conditions. Auriga Research operates an NABL-accredited TGA programme at the Manesar laboratory (USFDA Inspected facility at IMT Plot 136 Sector 5) providing pharmaceutical manufacturers, API producers and formulation scientists with the thermal decomposition, moisture content, residue on ignition and compositional data they need for regulatory submissions and process optimisation.

The TGA full form — Thermogravimetric Analysis — describes a technique where a sample is heated at a controlled rate (typically 10 C/min) from ambient temperature up to 1000 C while a precision microbalance continuously records the sample mass. Weight loss events correspond to specific thermal processes: evaporation of moisture and residual solvents below 150 C, desolvation of crystalline solvates between 100-250 C, decomposition of organic material above 200 C, and oxidation or reduction events depending on the atmosphere used. Our TGA platform operates under inert (nitrogen, argon) or oxidative (air, oxygen) atmospheres to characterise these events under different conditions.

Pharmaceutical applications of TGA analysis include determining residual solvent content in APIs per ICH Q3C(R8), quantifying bound and unbound moisture in hygroscopic materials per USP <731> Loss on Drying, residue on ignition per USP <281>, establishing the thermal stability window for processing and formulation, characterising polymorphic forms that differ in solvation state, and evaluating the composition of multi-component systems such as coated tablets or polymer-drug composites. When combined with DSC analysis and XRD at Baddi, TGA provides a complete solid-state thermal fingerprint that supports polymorph screening, stability assessment and CTD Module 3.2.S.3.1 dossier compilation.

TGA Equipment at Manesar

Thermogravimetric Analyser (TGA) instrument at Auriga Research Manesar USFDA Inspected laboratory — NABL accredited thermal analysis for loss on drying, residue on ignition and residual solvents

Auriga Research operates a research-grade thermogravimetric analyser at the Manesar laboratory — a USFDA Inspected facility at IMT Plot 136, Sector 5. The TGA platform supports thermal decomposition, moisture content, residue on ignition, residual solvent screening and oxidative stability under switchable atmospheres.

Lab location:
Auriga Manesar (USFDA Inspected)
Temperature range:
Ambient to 1000 °C
Atmospheres:
Nitrogen, air, oxygen, argon
Sample size:
5-15 mg typical
Pharmacopoeial / ICH coverage:
USP <731> Loss on Drying · USP <281> Residue on Ignition · ICH Q3C(R8) Residual Solvents
Accreditation:
NABL ISO/IEC 17025:2017

Specific make and model confirmation pending lab team sign-off; the platform delivers all listed pharmacopoeial and ICH services under NABL accreditation today.

TGA Analysis Services

Each service mapped to its pharmacopoeial or ICH reference for quick regulatory matching.

Decomp

Thermal Decomposition & Degradation Profile

Decomposition onset and degradation profile from ambient to 1000 C under nitrogen or air — defines processing and storage windows.

Moisture

Moisture & Volatile Content

Bound and unbound moisture, residual solvent and volatile content per USP <731> Loss on Drying and ICH Q3C(R8).

Ash

Residue on Ignition & Ash Content

Residue on ignition per USP <281> and inorganic ash content determination for APIs, excipients and finished products.

Compat

Excipient Compatibility by TGA

Drug-excipient compatibility screening by comparative TGA thermograms — flags thermal interactions early in formulation development.

Oxidative

Oxidative Stability Assessment

Oxidative stability under air or oxygen atmospheres — quantifies oxidation onset temperature and mass-gain kinetics.

Solid State

TGA in Solid-State Package

TGA delivered as part of a complete solid-state characterisation package alongside DSC and FTIR — single SPOC, single NABL report.

How It Works — 4 Steps to Your NABL TGA Report

1

Get a Quote

Share compound and characterisation question — moisture content, decomposition, residue on ignition or full solid-state thermal package. Your SPOC confirms temperature programme and atmosphere.

2

Collect and Send Your Sample

Prepare per SPOC instructions at quote stage. Each sample is bar-coded and registered in YLIMS on receipt with full chain-of-custody.

3

Testing and QA Review

Tested under NABL-accredited conditions at our Manesar facility. Results pass through formal QA review before release.

4

Receive Your NABL Report

NABL report delivered digitally within committed TAT, formatted for CDSCO, USFDA and regulatory submission. Track via YLIMS.

Project Timelines

Package Turnaround Time
Standard TGA Analysis 5-7 business days
Rush TGA Analysis 2-3 business days
Combined TGA + DSC Package 7-10 business days
Full Solid-State Package (TGA + DSC + XRD + FTIR) 10-14 business days

Who Needs TGA Analysis

  • ✓ Pharma formulators characterising moisture content and thermal stability of APIs and excipients
  • ✓ Generic developers requiring thermal characterisation data for CDSCO, USFDA or EMA dossiers
  • ✓ Stability teams monitoring thermal changes during ICH Q1A(R2) accelerated and long-term stability
  • ✓ CDMO clients needing TGA as part of a full solid-state characterisation package (TGA + DSC + XRD + FTIR)
  • ✓ API manufacturers quantifying residual solvent content per ICH Q3C(R8) by thermogravimetric methods
  • ✓ Polymorphism screening programmes requiring solvate and hydrate stoichiometry by TGA
  • ✓ Excipient suppliers documenting moisture and ash content for compendial release per USP and EP monographs
  • ✓ Regulatory affairs teams compiling solid-state characterisation data for CTD Module 3.2.S.3.1

Why Auriga for TGA Analysis

TGA + DSC + XRD Under One Roof

TGA at Manesar alongside DSC at Manesar and XRD at Baddi — commission a complete solid-state package from one organisation with one SPOC and one NABL report.

USFDA Inspected — Manesar

Auriga Manesar (IMT Plot 136 Sector 5) is a USFDA Inspected facility — TGA data is accepted in ANDA filings, USFDA dossiers and EMA submissions without re-testing.

Multi-Atmosphere Capability

Switchable atmosphere (nitrogen, air, oxygen, argon) so the same sample can be profiled for thermal decomposition, oxidative stability and inert ash in sequential runs.

Pharmacopoeial + ICH Coverage

USP <731> Loss on Drying, USP <281> Residue on Ignition and ICH Q3C(R8) residual solvent screening — all delivered on the same TGA platform.

Bar-Coded YLIMS Chain of Custody

Every sample is bar-coded and registered in YLIMS on receipt — full audit trail from logbook to report download, with NABL-accredited QA review before release.

Rush 2-3 Day TAT Available

Standard TGA in 5-7 business days; rush 2-3 days; full solid-state package (TGA + DSC + XRD + FTIR) in 10-14 business days for accelerated development timelines.

5+

NABL Labs

5 Cities

Delhi · Manesar · Bahadurgarh · Baddi · Bangalore

12,000+

Clients Served

1985

Arbro Group Established

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Frequently Asked Questions — TGA Analysis

What is TGA analysis and what does TGA stand for in pharma?
TGA stands for Thermogravimetric Analysis. It is a thermal analysis technique that measures the change in mass of a pharmaceutical substance as a function of temperature or time under a controlled atmosphere. In pharma, TGA analysis is used to determine moisture content, volatile residues, thermal decomposition temperatures, residue on ignition and ash content, and the composition of multi-component formulations. The technique heats a sample from ambient temperature up to 1000 C while continuously recording weight changes, providing precise data on thermal stability, desolvation and degradation behaviour.
What is the full form of TGA in pharmaceutical analysis?
The full form of TGA in pharma is Thermogravimetric Analysis. It is also referred to as thermogravimetry (TG). The technique belongs to the thermal analysis family alongside DSC (Differential Scanning Calorimetry) and DTA (Differential Thermal Analysis). TGA specifically measures mass changes, making it complementary to DSC which measures heat flow. Together, TGA and DSC provide a comprehensive thermal characterisation profile for pharmaceutical substances, excipients and formulations.
Where is the TGA instrument located at Auriga Research?
Auriga Research operates its TGA instrument at the Manesar laboratory — a USFDA Inspected facility located at IMT Manesar (Plot 136, Sector 5). TGA at Manesar sits alongside DSC at Manesar and XRD at Baddi, allowing customers to commission a complete solid-state characterisation package (TGA + DSC + XRD + FTIR) from a single organisation. All thermal analysis is performed under NABL ISO/IEC 17025:2017 accredited conditions with formal QA review before report release.
What types of pharmaceutical samples can be analysed by TGA?
TGA analysis is applicable to a wide range of pharmaceutical samples including active pharmaceutical ingredients (APIs), excipients, polymeric materials, coatings, drug-excipient mixtures and finished dosage forms. Common applications include determining residual solvent content in APIs per ICH Q3C(R8), quantifying moisture in hygroscopic excipients, evaluating thermal stability of heat-sensitive compounds, characterising polymorphic transitions involving desolvation, residue on ignition / ash content per USP <281>, and assessing the composition of multi-layer tablet coatings. The technique works with solid samples typically requiring only 5-15 mg of material.
How does TGA differ from DSC analysis?
TGA measures mass changes as a function of temperature, while DSC measures heat flow (energy changes). TGA detects events involving mass loss or gain — evaporation, decomposition, oxidation, desorption — but cannot detect events that occur without mass change, such as melting or glass transitions. DSC detects all thermal events including melting, crystallisation, glass transition and polymorphic transitions. For complete pharmaceutical characterisation, TGA and DSC are typically performed together to correlate mass-loss events with corresponding thermal transitions.
What is the typical turnaround time for TGA analysis?
Standard TGA analysis at Auriga Research is completed within 5-7 business days from sample receipt. This includes sample preparation, TGA measurement under the specified temperature programme and atmosphere, data analysis and report generation. Rush services are available within 2-3 business days for urgent characterisation needs. Combined TGA-DSC packages are completed within 7-10 business days, and a full solid-state characterisation package (TGA + DSC + XRD + FTIR) is delivered within 10-14 business days.

Need TGA Analysis for Your Pharmaceutical Samples?

NABL-accredited thermogravimetric analysis with 5-7 day turnaround. TGA at our USFDA Inspected Manesar facility — solid-state package available alongside DSC and XRD.

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